Symbol
Name
ID

Spo11
SPO11 initiator of meiotic double stranded breaks
MGI:1349669

Phenotype annotations related to reproductive system

Darker colors indicate more annotations

Mouse Phenotypes

decreased oocyte number

azoospermia

abnormal spermatid morphology

increased female germ cell apoptosis

abnormal ovary morphology

decreased mature ovarian follicle number

absent mature ovarian follicles

decreased primordial ovarian follicle number

impaired ovarian folliculogenesis

decreased ovary weight

small ovary

abnormal seminiferous tubule morphology

small seminiferous tubules

decreased testis weight

small testis

early reproductive senescence

abnormal reproductive system morphology

abnormal female reproductive system morphology

abnormal uterus development

abnormal gametogenesis

abnormal meiosis

abnormal chromosomal synapsis

abnormal female meiosis

abnormal male meiosis

abnormal X-Y chromosome synapsis during male meiosis

arrest of male meiosis

abnormal synaptonemal complex

abnormal oogenesis

abnormal spermatogenesis

arrest of spermatogenesis

abnormal male reproductive system morphology

female infertility

abnormal fertility/fecundity

male infertility

Availability

Mouse Genotype

Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc

Spo11^tm1Bdm/Spo11^tm1Bdm

Spo11^tm1Mjn/Spo11^tm1Mjn

Spo11^tm1Nki/Spo11^tm1Nki

Spo11^tm1Rdco/Spo11^tm1Rdco

Spo11^tm2.1Rdco/Spo11^tm2.1Rdco

Spo11^tm3Rdco/Spo11^tm3Rdco

Spo11^tm1.1Gvpc/Spo11^tm3Rdco

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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